Case Reports
Vol. 17 No. 2 (2025)
Tildrakizumab in the treatment of plaque psoriasis in an HIV+ patient: a case report and literature review of anti-interleukin drugs
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: 13 September 2024
Accepted: 22 October 2024
Accepted: 22 October 2024
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Treatment of psoriasis associated with human immunodeficiency virus (HIV) infection is challenging due to the high incidence of comorbidities and polypharmacy and the lack of evidence on the efficacy and safety of available drugs in these patients. Therefore, clinical or anecdotal reports provide useful indications for therapy decision-making. A 64-year-old male with plaque psoriasis (Psoriasis Area and Severity Index [PASI]=14.3) infected with HIV for 4 years, with hypercholesterolemia, hypertension, and impaired quality of life (Dermatology Life Quality Index [DLQI]=14) was resistant to topical therapy and acitretin. Tildrakizumab 200 mg was started, obtaining a PASI score of 0 at week 16, which was maintained after 13 months of follow-up. No adverse event was reported, and immune cell levels were unchanged. This is the first report on the treatment of psoriasis with tildrakizumab in an HIV+ patient. A literature search showed that prior to this patient, 38 HIV+ subjects had been treated with anti-cytokine agents for psoriasis.
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Citations
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How to Cite
1.
Lora V, Graceffa D, Di Prete M, Cota C. Tildrakizumab in the treatment of plaque psoriasis in an HIV+ patient: a case report and literature review of anti-interleukin drugs. Dermatol Reports [Internet]. 2024 Nov. 11 [cited 2026 May 25];17(2). Available from: https://journals.pagepress.net/dr/article/view/10140
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