Case Reports
Vol. 18 No. 1 (2026)
Spontaneous or photo-induced resolution of papular elastolytic giant cell granuloma? A case report with considerations on its etiopathogenesis and clinical approach
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: 27 December 2024
Accepted: 11 April 2025
Accepted: 11 April 2025
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Papular elastolytic giant cell granuloma (PEGCG) is a rare subtype of elastolytic giant cell granuloma (EGCG), typically presenting as asymptomatic papules in non-photo-exposed areas and lacking annular or photo-distributed lesions. Histologically, it overlaps with other EGCG variants, showing features like elastolysis, elastophagocytosis, and multinucleated giant cell infiltrates. The etiopathogenesis remains unclear, particularly the role of ultraviolet (UV) radiation, and its clinical management is not well defined. We report a case of PEGCG that, after a one-year history, achieved complete clinical remission following two and a half months of sun exposure during the summer (heliotherapy). This case offers insights into its etiopathogenesis and clinical management, supported by a review of the existing literature.
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Citations
1. O’Brien JP. Actinic granuloma. An annular connective tissue disorder affecting sun- and heat-damaged (elastotic) skin. Arch Dermatol 1975;111:460-6.
2. Qian YT, Liu JW, Liu W, et al. A Retrospective Study of 105 Patients with Elastolytic Giant Cell Granuloma and a Proposal for a New Clinical Classification. Acta Derm Venereol 2022;102:adv00684.
3. Gutiérrez-González E, Pereiro M Jr, Toribio J. Elastolytic Actinic Giant Cell Granuloma. Dermatol Clin 2015;33:331-41.
4. Parikh SA, Que SKT, Holmes WD, et al. Infiltrated papules on the trunk and headaches: A case of actinic granuloma and a review of the literature. Int J Womens Dermatol 2015;1:131-5.
5. Takata T, Ikeda M, Kodama H, Ohkuma S. Regression of papular elastolytic giant cell granuloma using narrow-band UVB irradiation. Dermatology 2006;212:77-9.
6. Chen WT, Hsiao PF, Wu YH. Spectrum and clinical variants of giant cell elastolytic granuloma. Int J Dermatol 2017;56:738-45.
7. Kato H, Uyeki Y, Yaoita H. Papular lesions associated with annular elastolytic giant cell granuloma. J Am Acad Dermatol 1989;21:398-400.
8. Morita K, Okamoto H, Miyachi Y. Papular elastolytic giant cell granuloma: a clinical variant of annular elastolytic giant cell granuloma or generalized granuloma annulare? Eur J Dermatol 1999;9:647-9.
9. Misago N, Ohtsuka Y, Ishii K, Narisawa Y. Papular and reticular elastolytic giant cell granuloma: rapid spontaneous regression. Acta Derm Venereol 2007;87:89-90.
10. Rongioletti F, Baldari M, Burlando M, Parodi A. Papular elastolytic giant cell granuloma: report of a case associated with monoclonal gammopathy and responsive to topical tacrolimus. Clin Exp Dermatol 2010;35:145-8.
11. Erdoğan HK, Arık D, Acer E, et al. Clinicopathological Features of Annular Elastolytic Giant Cell Granuloma Patients. Turk J Dermatol 2018;12:85-9.
12. Limas C. The spectrum of primary cutaneous elastolytic granulomas and their distinction from granuloma annulare: a clinicopathological analysis. Histopathology 2004;44:277-82.
13. de Oliveira FL, de Barros Silveira LK, Machado Ade M, Nery JA. Hybrid Clinical and Histopathological Pattern in Annular Lesions: An Overlap between Annular Elastolytic Giant Cell Granuloma and Granuloma Annulare? Case Rep Dermatol Med 2012;2012:102915.
14. Gambichler T. Mid-dermal elastolysis revisited. Arch Dermatol Res 2010;302:85-93.
15. Essegian DJ, Issa NT, Nichols A, Milikowski C. Rare presentation of the generalized papular variant of elastolytic giant cell granuloma associated with follicular lymphoma. JAAD Case Rep 2021;16:92-5.
16. Caldas R, Guimarães MJ, Rodrigues AP, Araújo C. Generalised papular variant of elastolytic giant cell granuloma. BMJ Case Rep 2019;12:e231580.
17. Hermes B, Haas N, Czarnetzki BM. Anuläres elastolytisches Riesenzellgranulom mit Spontanheilungstendenz [Annular elastolytic giant cell granuloma with a spontaneous healing tendency]. Hautarzt 1995;46:490-3.
18. Hohenleutner S, Wlotzke U, Landthaler M, Stolz W. Elastolysis of the mid-dermis and annular elastolytic giant cell granuloma: different stages in the clinical spectrum of dermal elastolysis? Case report and review of the literature. Hautarzt 1997;48:45-50.
19. O’Brien JP. Actinic granuloma: the expanding significance. An analysis of its origin in elastotic (“aging”) skin and a definition of necrobiotic (vascular), histiocytic, and sarcoid variants. Int J Dermatol 1985;24:473-90.
20. Heinz A. Elastic fibers during aging and disease. Ageing Res Rev 2021;66:101255.
How to Cite
1.
Marani A, Bertolla D, Caligiure A, Lombardi AR, Conti A. Spontaneous or photo-induced resolution of papular elastolytic giant cell granuloma? A case report with considerations on its etiopathogenesis and clinical approach. Dermatol Reports [Internet]. 2025 May 14 [cited 2026 May 21];18(1). Available from: https://journals.pagepress.net/dr/article/view/10149
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