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Primary cutaneous marginal zone lymphoma in a patient with multiple sclerosis under fingolimod therapy
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: 24 December 2024
Accepted: 17 May 2025
Accepted: 17 May 2025
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Authors
Dear Editor,
Increased prevalence of cancer, in particular lymphomas, has been observed in patients with multiple sclerosis (MS) treated with fingolimod. We report the first case of primary cutaneous marginal zone lymphoma (PCMZL) that developed under long-term fingolimod therapy for MS. [...]
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Citations
1. Askari M, Mirmosayyeb O, Ghaffary EM, et al. Incidence of cancer in patients with multiple sclerosis (MS) who were treated with fingolimod: A systematic review and meta-analysis. Mult Scler Relat Disord 2022;59:103680. DOI: https://doi.org/10.1016/j.msard.2022.103680
2. Wills A, Fan G, Kim E, et al. Primary cutaneous Epstein-Barr virus-positive diffuse large B-cell lymphoma (DLBCL) in a patient taking fingolimod. Dermatol Online J 2019;25:13030/qt2g62q2fq. DOI: https://doi.org/10.5070/D3259045508
3. Connolly A, Grandi V, Stefanato CM, et al. Primary cutaneous CD30+ anaplastic large-cell lymphoma associated with fingolimod. Br J Dermatol 2018;179:1400-1. DOI: https://doi.org/10.1111/bjd.17003
4. Froehlich A, Schmidt S, Landsberg J, et al. Spontaneous regression of tumor-stage cutaneous T-cell lymphoma in a multiple sclerosis patient after discontinuing fingolimod. Mult Scler 2018;24:1785-7. DOI: https://doi.org/10.1177/1352458518774444
5. Soma L, Crisan L, Reid J, et al. Epstein-Barr virus-positive, primary cutaneous marginal zone lymphoma, with transformation: Case report and review of the literature. Am J Clin Pathol 2024:aqae124. DOI: https://doi.org/10.1093/ajcp/aqae124
6. Stitt DW, Boes CJ, Flanagan EP, et al. A Case of cutaneous large B-cell lymphoma during treatment of multiple sclerosis with fingolimod. Mult Scler Relat Disord 2018;19:115-7. DOI: https://doi.org/10.1016/j.msard.2017.11.014
7. Awada Z, Hameed N, Harel A. Profile of Ofatumumab in the Treatment of Multiple Sclerosis: Design, Development and Place in Therapy. Drug Des Devel Ther 2024;18:5985-96. DOI: https://doi.org/10.2147/DDDT.S315174
How to Cite
1.
Gambichler T, Weyer-Fahlbusch SS, Werner M, Schade U, Bissels L, Susok L. Primary cutaneous marginal zone lymphoma in a patient with multiple sclerosis under fingolimod therapy. Dermatol Reports [Internet]. 2025 Jul. 11 [cited 2026 Apr. 18];. Available from: https://journals.pagepress.net/dr/article/view/10237
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