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https://doi.org/10.4081/dr.2026.10264

Exploring C5AR1 gene variants (rs11673309) and their impact on clinical features of chronic spontaneous urticaria

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Published: 11 February 2026
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Chronic spontaneous urticaria, C5AR1, rs11673309

Authors

Thi Xuan Tam Huynh
tamhtx@pnt.edu.vn
Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Viet Nam.
Duc Hau Truong
Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Viet Nam.

This study evaluated the genotype frequency of the rs11673309 single-nucleotide polymorphism (SNP) in the C5AR1 gene and its association with clinical features in Vietnamese chronic spontaneous urticaria (CSU) patients. A cross-sectional study was conducted on 102 patients at Ho Chi Minh City Hospital of Dermato-Venereology (Vietnam) from May to October 2023. Clinical data and 2 mL blood samples were collected, and SNP analysis was performed at Pham Ngoc Thach University’s Biomedical Research Center (Vietnam). Among 102 patients (29 males, 73 females; mean age: 37.6±12.5 years), three genotypes were identified: TT (32.4%), TG (49.0%), and GG (18.6%). The TT genotype showed the earliest disease onset (31.2±11.9 years, p=0.017). No significant association was observed between genotypes and Urticaria Activity Score (UAS; p=0.144), but a significant difference was found in Dermatology Life Quality Index (DLQI) scores (p=0.003). Furthermore, patients with the TG genotype required a higher dose of desloratadine (p<0.001). Patients with the TG genotype experienced lower quality of life, emphasizing the need for proactive management. These findings contribute to understanding the genetic basis of CSU in Vietnamese patients.

 

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1.
Huynh TXT, Truong DH. Exploring C5AR1 gene variants (rs11673309) and their impact on clinical features of chronic spontaneous urticaria. Dermatol Reports [Internet]. 2026 Feb. 11 [cited 2026 May 27];. Available from: https://journals.pagepress.net/dr/article/view/10264
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