Case Reports
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https://doi.org/10.4081/dr.2025.10284

Treatment of flat warts with trifarotene

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Published: 10 November 2025
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Flat warts, therapy, trifarotene

Authors

Gaetano Licata
gaetano.licata89@gmail.com
https://orcid.org/0000-0002-0834-1331
Dermatology Unit, San Antonio Abate Hospital, Trapani, Italy.
Eugenia Veronica Di Brizzi
https://orcid.org/0000-0002-0278-2443
Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy.
Elisabetta Fulgione
Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy.
Graziella Babino
Dermatology Unit, Department of Health Sciences, University of Basilicata, Potenza, Italy.
Vittorio Tancredi
Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy.
Filomena Barbato
Department of Pediatric Dermatology, Santobono-Pausilipon Children Hospital, Naples, Italy.
Giuseppe Argenziano
Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy.
Caterina Mariarosaria Giorgio
Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy.

This retrospective study explores the off-label use of trifarotene, a topical retinoid currently approved only for acne in individuals aged 12 years and older for the treatment of verrucae planae (flat warts). Our study included patients aged 3 to 45 years, demonstrating a high safety and tolerability profile due to the minimal systemic absorption of trifarotene. The therapy allowed for the rapid resolution of warts, avoiding invasive and potentially scarring treatments, particularly crucial for pediatric patients and young adults. These findings suggest that trifarotene may provide a cosmetically favorable and effective alternative for managing flat warts, warranting further investigation.

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How to Cite



1.
Licata G, Di Brizzi EV, Fulgione E, Babino G, Tancredi V, Barbato F, et al. Treatment of flat warts with trifarotene. Dermatol Reports [Internet]. 2025 Nov. 10 [cited 2026 May 31];. Available from: https://journals.pagepress.net/dr/article/view/10284
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