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https://doi.org/10.4081/dr.2026.10292

Hidradenitis suppurativa characterized by type 2-skewed inflammatory features when associated with atopic dermatitis: critical appraisal of a dupilumab-treated case report

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Published: 15 July 2026
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Atopic dermatitis, hidradenitis suppurativa, dupilumab

Authors

Niccolò Gori
niccologori89@gmail.com
Dermatology, Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome; Dermatology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Elena Ippoliti
Dermatology, Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome; Dermatology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Flaminia Antonelli
Dermatology, Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome; Dermatology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Ludovica Manieri
Dermatology, Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome; Dermatology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Ketty Peris
Dermatology, Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome; Dermatology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Atopic dermatitis (AD) and hidradenitis suppurativa (HS) are two common chronic inflammatory skin diseases associated with a significant impairment of patients’ quality of life. Although AD and HS are substantially different from a pathogenetic perspective, recent findings have indicated the existence of potential common pathogenetic mechanisms, including skin barrier alteration. We describe a 29-year-old male with concomitant HS and AD who obtained a marked improvement of both diseases under treatment with dupilumab, a monoclonal antibody that inhibits interleukin (IL)-4/IL-13 signaling. This finding supports the hypothesis that type 2 inflammation and skin barrier dysfunction play a significant role in the pathogenesis of HS.

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How to Cite



1.
Gori N, Ippoliti E, Antonelli F, Manieri L, Peris K. Hidradenitis suppurativa characterized by type 2-skewed inflammatory features when associated with atopic dermatitis: critical appraisal of a dupilumab-treated case report. Dermatol Reports [Internet]. 2026 Jul. 15 [cited 2026 Jul. 26];. Available from: https://journals.pagepress.net/dr/article/view/10292
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