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Papular acantholytic dyskeratosis of the genitocrural area with positive direct immunofluorescence in a man affected by lichen sclerosus et atrophicus: a clinicopathological challenge
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Published: 17 November 2025
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Dear Editor,
Papular acantholytic dyskeratosis (PAD) is a rare, sporadic, persistent disease of adulthood, localized to the genitocrural and anogenital regions. It was proposed as a new entity by Chorzelski et al. in 1984, based on the case of a 23-year-old woman with multiple, dome-shaped, white papules grouped on her vulva, which revealed histopathologically an epidermal proliferation with acantholysis and dyskeratosis, resembling both Haley-Haley (HHD) and Darier diseases (DD). Since then, PAD was reported as an asymptomatic/slightly itchy eruption of multiple white to skin-colored papules, coalescing to plaques, more commonly around the vulva. [...]
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Citations
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How to Cite
1.
Sacchi D, Lora V, Latini A, Di Prete M, Cota C. Papular acantholytic dyskeratosis of the genitocrural area with positive direct immunofluorescence in a man affected by lichen sclerosus et atrophicus: a clinicopathological challenge. Dermatol Reports [Internet]. 2025 Nov. 17 [cited 2026 Apr. 18];. Available from: https://journals.pagepress.net/dr/article/view/10658
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