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Complete remission of keratosis lichenoides chronica with abrocitinib
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Published: 8 June 2026
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Dear Editor,
Keratosis lichenoides chronica (KLC), also known as Nekam’s disease, is a rare and recalcitrant lichenoid dermatosis. It manifests with keratotic violaceous papules arranged in linear or reticulated patterns and typically follows a chronic and disabling course. Therapeutic guidelines are lacking, and conventional treatments – including corticosteroids, retinoids, immunosuppressants, and phototherapy – often fail to provide sustained benefit. Given its rarity, each therapeutic observation carries significant relevance. [...]
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Citations
1. Ozturk A, Acar A, Yaman B, Karaarslan I. Keratosis Lichenoides Chronica (Nekam's Disease): Dermoscopic and in Vivo Reflectance Confocal Microscopy Findings. Dermatol Pract Concept 2023;13:e2023232.
2. Giorgio CM, Di Brizzi EV, Balato A, et al. Dermoscopy in the Diagnosis of Keratosis Lichenoides Striata (Nekam Disease): A Rare Clinical Entity. Dermatol Pract Concept 2025;15:5108.
3. Tang J, Liu F, Liao W, Zhu G. Treatment of Keratosis Lichenoides Chronica With Upadacitinib. JAMA Dermatol 2024;160:681-2.
4. Damsky W, King BA. JAK inhibitors in dermatology: The promise of a new drug class. J Am Acad Dermatol 2017;76:736-44.
How to Cite
1.
Giorgio CM, Balato A, Argenziano G, Franzese P, Fulgione E, Cantelli M, et al. Complete remission of keratosis lichenoides chronica with abrocitinib. Dermatol Reports [Internet]. 2026 Jun. 8 [cited 2026 Jun. 24];. Available from: https://journals.pagepress.net/dr/article/view/10666
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