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https://doi.org/10.4081/dr.2026.10923

Line-field confocal optical coherence tomography for biopsy-site selection and treatment monitoring in plaque morphea

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Published: 25 June 2026
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Morphea, LC-OCT, non-invasive imaging, treatment monitoring

Authors

Giuseppe P. A. Gemma
Dermatology Clinic, Department of Medical and Cardiovascular Sciences, Sapienza University of Rome, Italy.
Carolina Dall'Ara
Dermatology Clinic, Department of Medical and Cardiovascular Sciences, Sapienza University of Rome, Italy.
Mirella Scattone
mirella.scattone@uniroma1.it
Dermatology Clinic, Department of Medical and Cardiovascular Sciences, Sapienza University of Rome, Italy.
Marco Virone
Dermatology Clinic, Department of Medical and Cardiovascular Sciences, Sapienza University of Rome, Italy.
Roberta De Carolis
Dermatology Clinic, Department of Medical and Cardiovascular Sciences, Sapienza University of Rome, Italy.
Luca Gargano
Dermatology Clinic, Department of Medical and Cardiovascular Sciences, Sapienza University of Rome, Italy.
Luca Fania
Istituto Dermopatico dell’Immacolata IRCCS, Dermatological Research Hospital, Rome; Department of Life Science, Health, and Health Professions, Link University of Rome, Italy.
Andrea Ascione
Department of Experimental Medicine, Policlinico Umberto I, Sapienza University of Rome, Italy.
Giovanni Pellacani
Dermatology Clinic, Department of Medical and Cardiovascular Sciences, Sapienza University of Rome, Italy.
Camilla Chello
Dermatology Clinic, Department of Medical and Cardiovascular Sciences, Sapienza University of Rome, Italy.

Dear Editor,

Morphea (localized scleroderma) is a cutaneous inflammatory fibrosing disorder characterized by heterogeneous clinical presentation and variable disease activity. Although diagnosis is predominantly clinical, accurate assessment of activity can be challenging, particularly in plaque-type disease where inflammatory and sclerotic components coexist. Non-invasive imaging may support the identification of active disease areas and help guide correct clinical management. [...]

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Citations

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1. Papara C, De Luca DA, Bieber K, et al. Morphea: The 2023 update. Front Med 2023;10:1108623.
2. Takahashi T, Takahashi T, Asano Y. Recent Advances in Localized Scleroderma. Sclerosis 2025;3:40.
3. Latriglia F, Ogien J, Tavernier C, et al. Line-Field Confocal Optical Coherence Tomography (LC-OCT) for Skin Imaging in Dermatology. Life (Basel) 2023;13:2268.
4. Traini DO, Palmisano G, Pinto LM, et al. Evaluation of localized scleroderma by line-field confocal optical coherence tomography. Ital J Dermatol Venerol 2026;161:77-8.

How to Cite



1.
Gemma GPA, Dall'Ara C, Scattone M, Virone M, De Carolis R, Gargano L, et al. Line-field confocal optical coherence tomography for biopsy-site selection and treatment monitoring in plaque morphea. Dermatol Reports [Internet]. 2026 Jun. 25 [cited 2026 Sep. 4];. Available from: https://journals.pagepress.net/dr/article/view/10923
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