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Unusual dermoscopic features of multiple pilomatricomas, including a rare bullous variant
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Published: 4 November 2025
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Dear Editor,
Pilomatricoma, or Malherbe’s calcifying epithelioma, is a benign neoplasm derived from hair follicle matrix cells. It usually presents as a solitary, firm, slow-growing subcutaneous nodule. Multiple pilomatricomas occur in about 2% of cases and may be associated with syndromes like Gardner’s syndrome, Turner syndrome, and myotonic dystrophy. The bullous variant is an exceptionally rare form that presents with an overlying blister due to lymphatic dilation. Fewer than 30 cases of bullous pilomatricoma have been reported, and even fewer cases have involved multiple lesions, making this report particularly noteworthy. [...]
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Citations
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3. Rajabi MT, Aghajani A, Rafizadeh SM, et al. Atypical and giant proliferating pilomatrixoma of the eyelid: a clinicopathological report. BMC Ophthalmol 2024;24:477. DOI: https://doi.org/10.1186/s12886-024-03748-4
4. Nakaso S, Ishii N, Akimoto M, Ogawa R. A paediatric case of multiple pilomatricomas: assessing the risk of genetic disorders. Clin Exp Dermatol 2025;50:1217-9. DOI: https://doi.org/10.1093/ced/llae461
5. Crawford M, Shi J, Kakadekar A, Sutherland A. Pilomatricoma presenting as a giant cutaneous horn in an 8-year-old child: A case report and literature review. SAGE Open Med Case Rep 2024;12:2050313X241284119. DOI: https://doi.org/10.1177/2050313X241284119
How to Cite
1.
Giorgio CM, Diplomatico M, Licata G, Damiani L, Esposito F, Di Brizzi EV, et al. Unusual dermoscopic features of multiple pilomatricomas, including a rare bullous variant. Dermatol Reports [Internet]. 2025 Nov. 4 [cited 2026 Apr. 18];. Available from: https://journals.pagepress.net/dr/article/view/10317
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