Case Reports
Vol. 18 No. 1 (2026)
https://doi.org/10.4081/dr.2021.9102

Skin-limited Langerhans cell histiocytosis in an adult

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Received: 15 February 2021
Accepted: 20 May 2021
Published: 29 July 2021
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Skin-limited, Langerhans cell histiocytosis, CD1a, S100, adult

Authors

Neringa Guobytė
n.guobyte@gmail.com
Center of Dermatovenereology, Vilnius University Hospital Santaros Klinikos, Lithuania.
Emilija Šerpytienė
Center of Dermatovenereology, Vilnius University Hospital Santaros Klinikos, Lithuania.
Monika Macejevska
https://orcid.org/0000-0002-3591-5564
Center of Dermatovenereology, Vilnius University Hospital Santaros Klinikos; Clinic of Infectious Diseases and Dermatovenereology, Institute of Clinical Medicine, Vilnius University, Lithuania.
Milda Krivickaitė
Center of Dermatovenereology, Vilnius University Hospital Santaros Klinikos, Lithuania.
Jūratė Grigaitienė
https://orcid.org/0000-0002-7734-0703
Center of Dermatovenereology, Vilnius University Hospital Santaros Klinikos; Clinic of Infectious Diseases and Dermatovenereology, Institute of Clinical Medicine, Vilnius University, Lithuania.

Langerhans cell histiocytosis (LCH) is an idiopathic group of disorders characterized histologically by proliferation and infiltration of tissue by Langerhans cell-type histiocytes. This disease can affect various organs. Patients with a single system lesion should be followed carefully. Detection of somatic BRAF-V600E mutation in circulating blood cells or in lesional biopsies has been associated with high-risk clinical characteristics. A 38-year-old male presented to our Dermatology Centre with a 3-month history of a small nodule on his right leg skin. Surgery to remove the lesion was performed. The diagnosis of skin-limited LCH was established. Due to possible systemic spread, the patient was referred to a hematologist for further evaluation. A full-body computed tomography (CT) scan did not show any infiltrates in other organs. Bone marrow aspirate and biopsy were performed; no Langerhans cells were detected. Sometimes skin lesions may represent the most clinically evident manifestation of potentially life-threatening multisystem disease.

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How to Cite



1.
Guobytė N, Šerpytienė E, Macejevska M, Krivickaitė M, Grigaitienė J. Skin-limited Langerhans cell histiocytosis in an adult. Dermatol Reports [Internet]. 2021 Jul. 29 [cited 2026 Apr. 18];18(1). Available from: https://journals.pagepress.net/dr/article/view/9102
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