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Case of generalized morphea complicated with systemic sclerosis

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Published: 6 October 2021
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Dear Editor,

Localized scleroderma (LSc; morphea) is a rare fibrosing disease of the skin and underlying tissues, which is different from systemic sclerosis (SSc). LSc is classified based on clinical presentations: circumscribed, linear, generalized, pansclerotic, and mixed morphea. Generalized morphea (GM), which is characterized by widespread skin lesions with multiple indurated plaques or hyperpigmentation, is a relatively rare subtype occurring in 7-9% of patients with LSc. Previous studies have shown that SSc can be complicated by GM, separately from GM-like SSc. Here, we present a rare case of coexistence of LSc and SSc in which LSc skin lesions appeared before SSc became apparent. [...]

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Citations

1. Laxer RM, Zulian F. Localized scleroderma. Curr Opin Rheumatol 2006;18:606-13.
2. LeRoy EC, Medsger TA Jr. Criteria for the classification of early systemic sclerosis. J Rheumatol 2001;28:1573-6.
3. Toki S, Motegi S, Yamada K, et al. Clinical and laboratory features of systemic sclerosis complicated with localized scleroderma. J Dermatol 2015;42:283-7.
4. Hayashi M, Ichiki Y, Kitajima Y. Coexistence of recurrent generalized morphea and systemic sclerosis. Acta Derm Venereol 2009;89:329-30.
5. Mizutani H, Tanaka H, Okada H, et al. Palindromic morphea: multiple recurrence of morphea lesions in a case of systemic sclerosis. J Dermatol 1992;19:298-301.

How to Cite



1.
Sawamura S, Makino K, Nakashima H, Makino T, Fukushima S. Case of generalized morphea complicated with systemic sclerosis. Dermatol Reports [Internet]. 2021 Oct. 6 [cited 2026 Apr. 18];18(1). Available from: https://journals.pagepress.net/dr/article/view/9382