A study on tumor necrosis factor-α single nucleotide polymorphisms and psoriasis vulgaris in Vietnam

This study aims to evaluate the association between tumor necrosis factor-α (TNF–α) single nucleotide polymorphisms and psoriasis vulgaris. This cross-sectional study involved 140 Vietnamese patients of Kinh ethnicity diagnosed with psoriasis vulgaris. The diagnosis of psoriasis vulgaris was based on clinical signs and symptoms. We used Sanger sequencing to analyze two single nucleotide polymorphisms (SNPs), rs1799964 and rs1799724. Data were analyzed by SPSS 25. SNP rs1799964 has the highest rate of TT genotype at 62.1%, more than double the heterozygous TC genotype at 30%, CC genotype has the lowest rate at 7.9%. CC genotype of SNP rs1799724 accounted for 90%, and no homozygous genotype TT was detected. No statistically significant association was found between both SNPs and clinical features (p>0.05). The Psoriasis Area and Severity Index (PASI) was significantly lower in patients with variant alleles (p=0.021). Our data show a significant negative association between SNP variant alleles and the disease’s severity. Studies with larger sample sizes and more biochemical indices may help identify reliably predictive markers for these SNPs.