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  23 | Combined immunotherapy with nivolumab and ipilimumab with and without sequential or concomitant stereotactic radiotherapy in patients with melanoma brain metastasis: an international retrospective study Maria Chiara Sergi*¹, Teresa Amaral*², Piotr Rutkowski*³, Marie-Lena Rasch², Naima Benannoune⁴, Patricio Serra⁵, Maria Grazia Vitale⁶, Diana Giannarelli⁷, Ana Maria Arance⁸, Eva Munoz Couselo⁹, Bart Neyns¹⁰, Iris Dirven¹¹, Marco Tucci¹², Michele Guida¹³, Francesco Spagnolo¹⁴, Ernesto Rossi¹⁵, Paola Queirolo¹⁶, Pietro Quaglino¹⁷, Roberta Depenni¹⁸, Joanna Placzke³, Anna Maria Di Giacomo¹⁹, Michele Del Vecchio²⁰, Alice Indini²⁰, Ines Pires da Silva²¹, Alexander M. Menzies²², Angela Hong²³, Paul Lorigan⁵, Caroline Robert²⁴, Georgina V. Long²², Paolo A. Ascierto⁶, Mario Mandalà²⁵ | ¹Unit of Medical Oncology, "Mons. A.R. Dimiccoli" Hospital, Asl BT, Barletta, Italy; ²Skin Cancer Clinical Trials Center, Department of Dermatology, Eberhard Karls University, Tuebingen, Germany. ³Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland. ⁴Gustave Roussy Cancer Campus, Villejuif, France. ⁵The University of Manchester, Manchester, UK. ⁶Department of Melanoma, Cancer Immunotherapy and Development Therapeutics, I.N.T. IRCCS Fondazione "G. Pascale" Napoli, Naples, Italy; ⁷Epidemiology and Biostatistics, Fondazione Policlinico Universitario, A. Gemelli IRCCS, Rome, Italy; ⁸Hospital Clínic Barcelona and IDIBAPS, Barcelona, Spain; ⁹Department of medical oncology. Vall d"Hebron Hospital, Barcelona, Spain & Vall d’Hebron Institute of oncology, VHIO. Barcelona, Spain; ¹⁰Department of Medical Oncology, UZ Brussel, Brussels, Belgium. ¹¹Department of medical oncology, Vrije Universiteit Brussel, VUB, Universitair Ziekenhuis Brussel, Brussels, Belgium; ¹²Medical Oncology Unit, University of Bari Aldo Moro, Policlinico Hospital of Bari, 70124 Bari, Italy. ¹³Rare Tumors and Melanoma Unit, IRCCS Istituto dei Tumori "Giovanni Paolo II," Bari, Italy. ¹⁴IRCCS Ospedale Policlinico San Martino, Skin Cancer Unit, Genova, Italy; ¹⁵Medical Oncology, Fondazione Policlinico Universitario, A. Gemelli IRCCS, Rome, Italy; ¹⁶IEO European Institute of Oncology, IRCCS, Milan, Italy. ¹⁷Department of Dermatology, University of Turin, Turin, Italy. ¹⁸University of Modena and Reggio Emilia, Department of Oncology, Hematology, Modena, Emilia-Romagna, Italy; ¹⁹Center for Immuno-Oncology, University Hospital of Siena, Siena, Italy. ²⁰Unit of Melanoma Medical Oncology, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; ²¹Melanoma Institute Australia, University of Sydney, and Blacktown Hospital, Sydney, New South Wales, Australia; ²²Melanoma Institute Australia, University of Sydney, and Royal North Shore and Mater Hospitals, Sydney, New South Wales, Australia; ²³Faculty of Medicine and Health, Sydney Medical School, The University of Sydney, Australia; Department of Radiation Oncology, Chris O'Brien Lifehouse, Camperdown, NSW, Australia; ²⁴Gustave Roussy and Paris-Saclay University, Villejuif, France; ²⁵Unit of Medical Oncology, University of Perugia, Perugia, Italy. ^§ on behalf of the Italian Melanoma Intergroup - IMI.

  Italian Melanoma Intergroup

  11-12-2025

  https://doi.org/10.4081/dr.2025.10765

  270
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  18 | Surgical management of pregnancy-associated melanoma: a single institution experience with thirty-three pregnant patients B. Taglione¹, I. Mattavelli¹, A. Maurichi¹, G. Gallino¹, D. Cortese¹, E. Tolomio¹, G. Spadola¹, C. Barbieri¹, S. Mercurio¹, B. Scoppio¹, B. Valeri², M. Cossa², M. Maccauro³, L. Di Guardo⁴, M. Del Vecchio⁴, M. Santinami¹, R. Patuzzo¹ | ¹IRCCS Istituto Nazionale Tumori Milano, Surgery, Milano; ²IRCCS Istituto Nazionale Tumori Milano, Pathology, Milano; ³IRCCS Istituto Nazionale Tumori Milano, Nuclear Medicine, Milano; ⁴IRCCS Istituto Nazionale Tumori Milano, Medical Oncology, Milano, Italy.

  Italian Melanoma Intergroup

  11-12-2025

  https://doi.org/10.4081/dr.2025.10760

  316
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  36 | Neoadjuvant strategy for locally advanced conjunctival melanoma: a single-center approach to eye preservation F. Rifaldi^1|2, M. Angi³, L. Giuseppe¹, F. Lanza³, A. Spagnoletti¹, J. Sergenti³, A. Indini¹, E. Mastrogiuseppe³, M. Del Vecchio¹, L. Di Guardo¹ | ¹Melanoma Medical Oncology Unit, Department of Medical Oncology ed Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan; ²Fondazione IRCCS Policlinico San Matteo, Pavia; ³Ocular Oncology Service, Department of Surgical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

  Italian Melanoma Intergroup

  11-12-2025

  https://doi.org/10.4081/dr.2025.10778

  355