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  23 | Combined immunotherapy with nivolumab and ipilimumab with and without sequential or concomitant stereotactic radiotherapy in patients with melanoma brain metastasis: an international retrospective study Maria Chiara Sergi*¹, Teresa Amaral*², Piotr Rutkowski*³, Marie-Lena Rasch², Naima Benannoune⁴, Patricio Serra⁵, Maria Grazia Vitale⁶, Diana Giannarelli⁷, Ana Maria Arance⁸, Eva Munoz Couselo⁹, Bart Neyns¹⁰, Iris Dirven¹¹, Marco Tucci¹², Michele Guida¹³, Francesco Spagnolo¹⁴, Ernesto Rossi¹⁵, Paola Queirolo¹⁶, Pietro Quaglino¹⁷, Roberta Depenni¹⁸, Joanna Placzke³, Anna Maria Di Giacomo¹⁹, Michele Del Vecchio²⁰, Alice Indini²⁰, Ines Pires da Silva²¹, Alexander M. Menzies²², Angela Hong²³, Paul Lorigan⁵, Caroline Robert²⁴, Georgina V. Long²², Paolo A. Ascierto⁶, Mario Mandalà²⁵ | ¹Unit of Medical Oncology, "Mons. A.R. Dimiccoli" Hospital, Asl BT, Barletta, Italy; ²Skin Cancer Clinical Trials Center, Department of Dermatology, Eberhard Karls University, Tuebingen, Germany. ³Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland. ⁴Gustave Roussy Cancer Campus, Villejuif, France. ⁵The University of Manchester, Manchester, UK. ⁶Department of Melanoma, Cancer Immunotherapy and Development Therapeutics, I.N.T. IRCCS Fondazione "G. Pascale" Napoli, Naples, Italy; ⁷Epidemiology and Biostatistics, Fondazione Policlinico Universitario, A. Gemelli IRCCS, Rome, Italy; ⁸Hospital Clínic Barcelona and IDIBAPS, Barcelona, Spain; ⁹Department of medical oncology. Vall d"Hebron Hospital, Barcelona, Spain & Vall d’Hebron Institute of oncology, VHIO. Barcelona, Spain; ¹⁰Department of Medical Oncology, UZ Brussel, Brussels, Belgium. ¹¹Department of medical oncology, Vrije Universiteit Brussel, VUB, Universitair Ziekenhuis Brussel, Brussels, Belgium; ¹²Medical Oncology Unit, University of Bari Aldo Moro, Policlinico Hospital of Bari, 70124 Bari, Italy. ¹³Rare Tumors and Melanoma Unit, IRCCS Istituto dei Tumori "Giovanni Paolo II," Bari, Italy. ¹⁴IRCCS Ospedale Policlinico San Martino, Skin Cancer Unit, Genova, Italy; ¹⁵Medical Oncology, Fondazione Policlinico Universitario, A. Gemelli IRCCS, Rome, Italy; ¹⁶IEO European Institute of Oncology, IRCCS, Milan, Italy. ¹⁷Department of Dermatology, University of Turin, Turin, Italy. ¹⁸University of Modena and Reggio Emilia, Department of Oncology, Hematology, Modena, Emilia-Romagna, Italy; ¹⁹Center for Immuno-Oncology, University Hospital of Siena, Siena, Italy. ²⁰Unit of Melanoma Medical Oncology, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; ²¹Melanoma Institute Australia, University of Sydney, and Blacktown Hospital, Sydney, New South Wales, Australia; ²²Melanoma Institute Australia, University of Sydney, and Royal North Shore and Mater Hospitals, Sydney, New South Wales, Australia; ²³Faculty of Medicine and Health, Sydney Medical School, The University of Sydney, Australia; Department of Radiation Oncology, Chris O'Brien Lifehouse, Camperdown, NSW, Australia; ²⁴Gustave Roussy and Paris-Saclay University, Villejuif, France; ²⁵Unit of Medical Oncology, University of Perugia, Perugia, Italy. ^§ on behalf of the Italian Melanoma Intergroup - IMI.

  Italian Melanoma Intergroup

  11-12-2025

  https://doi.org/10.4081/dr.2025.10765

  292
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  35 | Real-world outcomes of targeted therapy in stage IV melanoma after relapse on adjuvant dabrafenib and trametinib: insights from a single-center cohort Rossella Villani, Chiara Bungaro, Anna Cecere, Ileana De Roma, Sabino Strippoli, Michele Guida | Rare Tumors and Melanoma Unit, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy.

  Italian Melanoma Intergroup

  11-12-2025

  https://doi.org/10.4081/dr.2025.10777

  345
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  34 | Dissecting the spectrum of rare BRAF mutations in melanoma: a nation-wide study by the Italian Melanoma Intergroup Francesco Spagnolo^1|2, Bruna Dalmasso³, Maria Chiara Scaini⁴, Laura Cendron⁵, Monica Rodolfo⁶, Ilaria Mattavelli⁷, Elena Tamborini⁸, Francesca Collina⁹, Gerardo Ferrara, Gabriele Madonna¹⁰, Carlo Cota¹¹, Elisa Melucci¹², Stefania Tommasi¹³, Martina Ubaldi¹⁴, Roberta Depenni¹⁵, Andrea Carugno¹⁶, Riccardo Marconcini¹⁷, Laura Orgiano¹⁸, Maurizio Lombardo¹⁹, Simona Sola²⁰, Cristina Pellegrini²¹, Francesca Castiglione²², Matteo Gasparotto^5|23, Alireza Jorkesh⁵, Stefania Pellegrini⁴, Edoardo Raposio¹, Andrea Boutros², Enrica Teresa Tanda², Michele Guida²⁵, Pietro Quaglino²⁶, Giuseppe Palmieri²⁷, Daniela Massi²², Paolo Antonio Ascierto¹⁰, Mario Mandalà*²⁸, Chiara Menin*⁴, Paola Ghiorzo*²⁴, Lorenza Pastorino*²⁴, for the Italian Melanoma Intergroup²⁹ | ¹Department of Surgical Sciences and Integrated Diagnostics, DISC, Plastic Surgery Division, University of Genoa; ²IRCCS Ospedale Policlinico San Martino, Genova; ³IRCCS Ospedale Policlinico San Martino, Cancer Genetics, Genoa; ⁴Immunology and Molecular Oncology Unit, Veneto Institute of Oncology - IOV IRCCS, Padua; ⁵Department of Biology, University of Padua, Padua; ⁶Unit of Translational Immunology, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan; ⁷Melanoma Surgical Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan; ⁸Department of Diagnostic Innovation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan; ⁹Pathology Unit, Istituto Nazionale Tumori, IRCCS - Fondazione G. Pascale, Napoli; ¹⁰Melanoma, Cancer Immunotherapy and Innovative Therapies Unit, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli; ¹¹Dermatopathology Unit, San Gallicano Dermatological Institute IRCCS, Rome; ¹²Pathology Unit, IRCCS Regina Elena, National Cancer Institute, Rome; ¹³Molecular Diagnostics and Pharmacogenetics Unit, IRCCS Istituto Tumori "Giovanni Paolo II", Bari; ¹⁴Unit of Medical Oncology, University of Perugia; ¹⁵Department of Oncology and Hematology, University of Modena and Reggio Emilia, Modena; ¹⁶Department of Medicine and Surgery, University of Insubria, Varese; ¹⁷Medical Oncology Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa; ¹⁸Department of Medical Oncology, University of Cagliari, Cagliari; ¹⁹Division of Dermatology, Department of Medicine and Surgery, Ospedale di Circolo e Fondazione Macchi, ASST dei Sette Laghi, Varese; ²⁰Surgical Pathology, Galliera Hospital, Genoa; ²¹Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila; ²²Histopathology and Molecular Diagnostics, Careggi University Hospital, Florence, Italy and Section of Pathology, Department of Health Sciences, University of Florence, Italy; ²³Department of Translational Brain Research, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. ²⁴Department of Internal Medicine and Medical Specialties, University of Genoa; ²⁵Rare Tumors and Melanoma Unit, IRCCS Istituto Tumori Giovanni Paolo II, Bari; ²⁶Dermatology Clinic, Department of Medical Sciences, University of Turin; ²⁷Immuno-Oncology & Targeted Cancer Biotherapies, University of Sassari - Unit of Cancer Genetics, IRGB-CNR, Sassari; ²⁸University of Perugia, Medical Oncology Unit, Santa Maria Misericordia Hospital, Perugia; ²⁹Italian Melanoma Intergroup, IMI, Italy. *These authors equally contributed to this work.

  Italian Melanoma Intergroup

  11-12-2025

  https://doi.org/10.4081/dr.2025.10776

  320
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  13 | Spatial contexture of tertiary lymphoid structures as a predictor of recurrence in early-stage melanoma Chiara Bungaro¹, Sabino Strippoli¹, Daniele Carenza¹, Ivana De Risi¹, Rossella Villani¹, Teresa Squicciarini¹, Anna Albano¹, Ileana De Roma¹, Fabio Mele ², Margherita Sonnessa², Concetta Saponaro², Francesco Alfredo Zito², Arianna Bozzi³, Benedetta Apollonio¹, Raffaella Massafra³, Michele Guida¹ | ¹Rare Tumors and Melanoma Unit, IRCCS Istituto Tumori "Giovanni Paolo II"; ²Pathology Unit, IRCCS Istituto Tumori "Giovanni Paolo II"; ³Biostatistics and Bioinformatics Unit, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy.

  Italian Melanoma Intergroup

  11-12-2025

  https://doi.org/10.4081/dr.2025.10755

  337
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  09 | Integration of hematoxylin and eosin and immunohistochemistry images to improve AI-based recurrence prediction in negative sentinel lymphnode melanoma patients Maria Colomba Comes¹, Andrea Lupo¹, Fabio Mele², Concetta Saponaro², Arianna Bozzi¹, Ivana De Risi³, Samantha Bove¹, Annarita Fanizzi¹, Benedetta Apollonio³, Margherita Sonnessa², Sabino Strippoli³, Francesco Alfredo Zito², Michele Guida³, Raffaella Massafra¹ | ¹Biostatistics and Bioinformatics Unit, IRCCS Istituto Tumori "Giovanni Paolo II"; ²Pathology Unit, IRCCS Istituto Tumori "Giovanni Paolo II"; ³Rare Tumors and Melanoma Unit, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy.

  Italian Melanoma Intergroup

  11-12-2025

  https://doi.org/10.4081/dr.2025.10751

  316