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Maculopapular sarcoidosis: the importance of skin signs
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41 | METABOLIC DYSREGULATION AND IMMUNE ACTIVATION IN VITILIGO: UNVEILING THE MITOCHONDRIAL AND INFLAMMATORY IMPRINT OF DISEASE PATHOGENESIS S. Caputo1, A. Marini1, S. Scano1, F. Papaccio1, R. Marrapodi1, P. Iacovelli2, A. Presaghi3, E. Migliano3, C. Cota4, A. Filoni5, M. Picardo6, B. Bellei1 | 1Laboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatological Institute, IRCCS, Rome, Italy; 2Clinical Dermatology, Phototherapy Unit, San Gallicano Dermatological Institute, IRCCS, Rome, Italy; 3Department of Plastic and Regenerative Surgery, San Gallicano Dermatological Institute, IRCCS, Rome, Italy; 4Genetic Research, Molecular Biology and Dermatopathology Unit, San Gallicano Dermatological Institute, Rome, Italy; 5UOSVD Dermatology and Allergology, Hospital Vito Fazzi, Lecce, Italy; 6Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome, Italy
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55 | PAEDIATRIC FOLLICULAR MUCINOSIS WITHOUT PROGRESSION TO MYCOSIS FUNGOIDES: A LONG-TERM CLINICOPATHOLOGIC STUDY A. Di Guardo1, L. Ambrosio1|2, M. Testa1, D. Didona1, F. Moro1|2, A. Rallo1, G. Di Lella1, L. Colonna1, S. Pallotta1, A. Panebianco1, L. Fania1|3 | 1IDI-IRCCS, Dermatological Research Hospital, Rome, Italy; 2UOC of Dermatology, Department of Medical and Cardiovascular Sciences, “Sapienza” University of Rome, Italy; 3Department of Life Science, Health, and Health Professions, Link University of Rome, Italy
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57 | GENERALIZED PLANE XANTHOMA AND NECROBIOTIC XANTOGRANULOMA HERALDING PROGRESSION FROM MGUS TO MULTIPLE MYELOMA: COMPLETE CUTANEOUS RESOLUTION AFTER MYELOMA-DIRECTED THERAPY M. Di Prete1, V. Lora2, C. Cota1 | 1Dermatopathology Research Unit, San Gallicano Dermatological Institute IRCCS, Rome, Italy; 2Clinical Dermatology, San Gallicano Dermatological Institute IRCCS, Rome, Italy
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34 | Dissecting the spectrum of rare BRAF mutations in melanoma: a nation-wide study by the Italian Melanoma Intergroup Francesco Spagnolo1|2, Bruna Dalmasso3, Maria Chiara Scaini4, Laura Cendron5, Monica Rodolfo6, Ilaria Mattavelli7, Elena Tamborini8, Francesca Collina9, Gerardo Ferrara, Gabriele Madonna10, Carlo Cota11, Elisa Melucci12, Stefania Tommasi13, Martina Ubaldi14, Roberta Depenni15, Andrea Carugno16, Riccardo Marconcini17, Laura Orgiano18, Maurizio Lombardo19, Simona Sola20, Cristina Pellegrini21, Francesca Castiglione22, Matteo Gasparotto5|23, Alireza Jorkesh5, Stefania Pellegrini4, Edoardo Raposio1, Andrea Boutros2, Enrica Teresa Tanda2, Michele Guida25, Pietro Quaglino26, Giuseppe Palmieri27, Daniela Massi22, Paolo Antonio Ascierto10, Mario Mandalà*28, Chiara Menin*4, Paola Ghiorzo*24, Lorenza Pastorino*24, for the Italian Melanoma Intergroup29 | 1Department of Surgical Sciences and Integrated Diagnostics, DISC, Plastic Surgery Division, University of Genoa; 2IRCCS Ospedale Policlinico San Martino, Genova; 3IRCCS Ospedale Policlinico San Martino, Cancer Genetics, Genoa; 4Immunology and Molecular Oncology Unit, Veneto Institute of Oncology - IOV IRCCS, Padua; 5Department of Biology, University of Padua, Padua; 6Unit of Translational Immunology, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan; 7Melanoma Surgical Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan; 8Department of Diagnostic Innovation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan; 9Pathology Unit, Istituto Nazionale Tumori, IRCCS - Fondazione G. Pascale, Napoli; 10Melanoma, Cancer Immunotherapy and Innovative Therapies Unit, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli; 11Dermatopathology Unit, San Gallicano Dermatological Institute IRCCS, Rome; 12Pathology Unit, IRCCS Regina Elena, National Cancer Institute, Rome; 13Molecular Diagnostics and Pharmacogenetics Unit, IRCCS Istituto Tumori "Giovanni Paolo II", Bari; 14Unit of Medical Oncology, University of Perugia; 15Department of Oncology and Hematology, University of Modena and Reggio Emilia, Modena; 16Department of Medicine and Surgery, University of Insubria, Varese; 17Medical Oncology Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa; 18Department of Medical Oncology, University of Cagliari, Cagliari; 19Division of Dermatology, Department of Medicine and Surgery, Ospedale di Circolo e Fondazione Macchi, ASST dei Sette Laghi, Varese; 20Surgical Pathology, Galliera Hospital, Genoa; 21Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila; 22Histopathology and Molecular Diagnostics, Careggi University Hospital, Florence, Italy and Section of Pathology, Department of Health Sciences, University of Florence, Italy; 23Department of Translational Brain Research, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. 24Department of Internal Medicine and Medical Specialties, University of Genoa; 25Rare Tumors and Melanoma Unit, IRCCS Istituto Tumori Giovanni Paolo II, Bari; 26Dermatology Clinic, Department of Medical Sciences, University of Turin; 27Immuno-Oncology & Targeted Cancer Biotherapies, University of Sassari - Unit of Cancer Genetics, IRGB-CNR, Sassari; 28University of Perugia, Medical Oncology Unit, Santa Maria Misericordia Hospital, Perugia; 29Italian Melanoma Intergroup, IMI, Italy. *These authors equally contributed to this work.
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